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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP14
All Species:
33.64
Human Site:
Y285
Identified Species:
49.33
UniProt:
P54578
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54578
NP_001032411.1
494
56069
Y285
F
I
N
Q
E
V
K
Y
L
F
T
G
L
K
L
Chimpanzee
Pan troglodytes
P60051
493
55922
Y285
F
I
N
Q
E
V
K
Y
L
F
T
G
L
K
L
Rhesus Macaque
Macaca mulatta
XP_001090667
458
52239
L257
Y
L
F
T
G
L
K
L
R
L
Q
E
E
I
T
Dog
Lupus familis
XP_537306
545
61461
Y336
F
I
N
Q
E
V
K
Y
L
F
T
G
L
K
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9JMA1
493
55983
Y285
F
I
N
Q
E
V
K
Y
L
F
T
G
L
K
L
Rat
Rattus norvegicus
NP_001008302
493
55958
Y285
F
I
N
Q
E
V
K
Y
L
F
T
G
L
K
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519267
431
48760
R230
L
F
T
G
L
K
L
R
L
Q
E
E
I
T
K
Chicken
Gallus gallus
XP_419150
492
55612
Y283
F
I
S
Q
E
V
K
Y
L
F
T
G
L
K
L
Frog
Xenopus laevis
Q6GNI6
523
60030
N281
R
H
C
K
G
D
D
N
G
K
K
A
N
N
P
Zebra Danio
Brachydanio rerio
A6H8I0
506
58102
D289
F
T
G
G
L
Q
S
D
V
T
C
Q
V
C
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609377
475
53689
Y272
F
I
S
M
D
V
K
Y
M
Q
S
G
L
K
S
Honey Bee
Apis mellifera
XP_395043
497
56311
Y280
F
I
S
T
E
V
K
Y
M
H
S
G
L
R
N
Nematode Worm
Caenorhab. elegans
Q17361
489
55859
A262
F
L
Q
T
G
I
K
A
G
F
E
E
E
M
T
Sea Urchin
Strong. purpuratus
XP_786966
516
58357
Y286
F
I
T
Q
E
V
K
Y
L
H
T
G
L
K
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q949Y0
482
53677
H265
H
I
S
H
E
V
N
H
L
H
E
G
L
K
H
Baker's Yeast
Sacchar. cerevisiae
P43593
499
57092
F271
H
I
S
G
T
T
N
F
M
R
N
G
L
L
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
92.5
89.9
N.A.
96.7
96.5
N.A.
80.3
90.4
21.4
20.1
N.A.
54.6
61.7
41.9
61
Protein Similarity:
100
99.8
92.7
90.2
N.A.
98.5
98.7
N.A.
83.8
94.9
39
38.7
N.A.
71.2
80.2
61.1
76.5
P-Site Identity:
100
100
6.6
100
N.A.
100
100
N.A.
6.6
93.3
0
6.6
N.A.
53.3
53.3
20
80
P-Site Similarity:
100
100
26.6
100
N.A.
100
100
N.A.
13.3
100
6.6
20
N.A.
80
80
33.3
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.5
26
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.9
46.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
46.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
7
0
0
0
7
0
0
0
% A
% Cys:
0
0
7
0
0
0
0
0
0
0
7
0
0
7
0
% C
% Asp:
0
0
0
0
7
7
7
7
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
57
0
0
0
0
0
19
19
13
0
7
% E
% Phe:
69
7
7
0
0
0
0
7
0
44
0
0
0
0
0
% F
% Gly:
0
0
7
19
19
0
0
0
13
0
0
69
0
0
0
% G
% His:
13
7
0
7
0
0
0
7
0
19
0
0
0
0
13
% H
% Ile:
0
69
0
0
0
7
0
0
0
0
0
0
7
7
0
% I
% Lys:
0
0
0
7
0
7
69
0
0
7
7
0
0
57
7
% K
% Leu:
7
13
0
0
13
7
7
7
57
7
0
0
69
7
38
% L
% Met:
0
0
0
7
0
0
0
0
19
0
0
0
0
7
0
% M
% Asn:
0
0
32
0
0
0
13
7
0
0
7
0
7
7
13
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% P
% Gln:
0
0
7
44
0
7
0
0
0
13
7
7
0
0
0
% Q
% Arg:
7
0
0
0
0
0
0
7
7
7
0
0
0
7
0
% R
% Ser:
0
0
32
0
0
0
7
0
0
0
13
0
0
0
7
% S
% Thr:
0
7
13
19
7
7
0
0
0
7
44
0
0
7
13
% T
% Val:
0
0
0
0
0
63
0
0
7
0
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
57
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _